ensemble数据库？核酸序列数据库(genbank)和基因组数据库(ensemble)的区别
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核酸序列数据库(genbank)和基因组数据库(ensemble)的区别
核酸序列数据库（genbank）和基因组数据库（ensemble）的区别：
1、GenBank是一个有来自于70,000多种生物的核苷酸序列的数据库。每条纪录都有编码区（CDS）特征的注释，还包括氨基酸的翻译。GenBank属于一个序列数据库的国际合作组织，包括EMBL和DDBJ。
2、Ensemble数据库可为药物研发提供超过167,000种生物活性化合物包括化学结构在内的必要信息。本数据库利用用户容易掌握的界面将数据、文本和图象资料有机地结合起来，便于查询。Ensemble可从药品专利开始，再通过其临床前和临床研究资料，直至注册信息、市场概况及其他方面的相关资料来跟踪药物。数据库每月更新一次，每年增加约10,000种新化合物。
请教关于intersystems 的cache数据库的相关知识
1、安装cache之前必须先安装IIS。//用来解析CSP
IIS在控制面板->添加或删除程序->添加/删除Windows组件->Internet信息服务(IIS)添加；
2、cache(Ensemble)安装步骤总共十二步;
3.安装完成后 shutdown数据库。
4.拷贝原库Cache.cpf到EnsembleSys根目录下，cpf中主要配置数据库存放路径，根据事情情况可以自己修改cpf文件，或者在
System management Portal->Local Databases->Home->Configuration->Local Databases->Edit;
5.拷贝Cache.key到EnsembleSys\Mgr根目录下；
CSP的配置
按照原库路径配置以下内容
1、设置路径： [Home]> [Security Management]> [CSP Applications]> [Create NEW CSP Application]>[Save]；
2、Csp Application路径为IE访问路径
3、Resource required to run the application:%Service CSP;
4、Namespace:————————;
5、CachePhysicalPath:“数据库存放路径”
6、Default Superclass: locale.Chinese
CSP Gateway Management的设置
设置路径[Home]> [Configuration]>[CSP Gateway Management]
Server Access（一般安装数据库后自动生成）
Application Access（需要添加一个）
IIS中虚拟目录设置//只使用数据库不考虑
操作路径：控制面板->管理工具->Internet信息服务->(本地计算机->网站->默认网站)。如果以前添加了站点，那么在完成上一步CSP设置之后，需要删除原来的IIS站点，重新添加。
此处注意权限。
对上面操作步骤说明
1、虚拟目录别名为
2、第四步目录名称必须指向数据存放路径下，
3、第四步执行权限全选；//写CLS CSP需要配置
补丁操作
注意：在做补丁之前需要把CACHELIB的ReadOnly更改为No，做完补丁后再更改回Yes。
将以下内容拷贝到C:\EnsembleSys\Mgr\FDBMS
Patch\FDBMS_F173_Cache_52_WNT下CACHE.DAT文件
Patch\ qaqcasl523.mro文件
将以下内容拷贝到C:\EnsembleSys\CSP\sys\mgr
Patch\adhoc5412plus\adhoc5412\UtilConfigSQL.csp
%SYS>zn"fdbms"
FDBMS>d ^mdbmsins("","FDBMS")
Converting User Security Definitions.....DONE
CONVERTING USER PASSWORDS...
ALL DONE
FDBMS>d integ^mdbmsins()
FDBMS>d ^%RIMF
Load routines from a%ROMF file.
WARNING: This routine will delete the source code(if any)
for existing object routines that are being replaced.
Device: C:\patch\FDBMS_F173_Cache_52_WNT\qarmacF173.mro
file format:("UR")=>
M/WNT wrote this file on Nov 03 2006 3:03 PM.
File Comment: patch for compiling routines in FDBMS
( All Select Enter List Quit)
Routine Input Option: all
If a selected routine has the same name as one already on file,
shall it replace the one on file? No=> yes
Building existing routine list... done.
@ indicates routines which have been saved to disk.
. indicates routines which already exist in this directory.
Loading Routines...
%qarmac@.
1 routine in 0 minutes, 0 seconds
none of them skipped.
FDBMS>
FDBMS>d ^%RIMF
Load routines from a%ROMF file.
WARNING: This routine will delete the source code(if any)
for existing object routines that are being replaced.
Device: C:\patch\FDBMS_F173_Cache_52_WNT\SYS.SQLSRV.mro
file format:("UR")=>
M/WNT wrote this file on Nov 03 2006 3:03 PM.
File Comment: patch for compiling routines in FDBMS
( All Select Enter List Quit)
Routine Input Option: all
If a selected routine has the same name as one already on file,
shall it replace the one on file? No=> yes
Building existing routine list... done.
@ indicates routines which have been saved to disk.
. indicates routines which already exist in this directory.
Loading Routines...
FDBMS>
再做adhoc5412plus.zip（如文档readme_5412.txt，需要拷贝UtilConfigSQL.csp到C:\EnsembleSys\CSP\sys\mgr下）；
FDBMS>zn"%sys"
%SYS>d ^%RI
Input routines from Sequential
Device: C:\patch\adhoc5412plus\adhoc5412\adhoc5412.rsa
Parameters?"RS"=>
File written by Cache for Windows using%RO on 17 May 2007 9:32 PM
with extensions INC,INT and with description:
( All Select Enter List Quit)
Routine Input Option: all
If a selected routine has the same name as one already on file,
shall it replace the one on file? No=> yes
Generate backups? No=> No
Recompile? Yes=> yes
Display Syntax Errors? Yes=> yes
^ indicates routines which will replace those now on file.
@ indicates routines which have been [re]compiled.
- indicates routines which have not been filed.
%msql.INC^ syConfig.INC^ STUCNFG1.INT@
3 routines processed.
%SYS>s path="C:\patch\adhoc5412plus\adhoc5412\SQL.xml"
%SYS>do$SYSTEM.OBJ.Load(path,"cbrps")
Load started on 04/12/2008 10:56:40
Loading file C:\patch\adhoc5412plus\adhoc5412\SQL.xml as xml
Imported class:%SYSTEM.SQL
Compiling class%SYSTEM.SQL
Compiling routine%SYSTEM.SQL.1
ERROR: Compiling class includes
Processing%systemInclude.INC into a precompiled header
Load finished successfully.
%SYS>s path="C:\patch\adhoc5412plus\adhoc5412\adhoc5412.xml"
%SYS>do$SYSTEM.OBJ.Load(path,"brpsu")
Load started on 04/12/2008 10:57:57
Loading file C:\patch\adhoc5412plus\adhoc5412\adhoc5412.xml as xml
Imported object code:%SYS.PATCH
Imported global: ^CacheTempPatch
Load finished successfully.
%SYS>do ^%MGDIR
You're in namespace%SYS
Default directory is c:\ensemblesys\mgr\
%SYS>do ^%SYS.PATCH
Apply Patch Utility
Adhoc: 5412
Description: PVA089,DPV2673
Created at: 2007-05-18 00:51:28
Created on$zv: Cache for Windows(Intel) 5.2.3(Build 710)
Apply(Y/N) y
Applying Patch...
.......
Successfully Applied!
Please test the patch. If it fails, you can remove the
patch by executing the following command:
Do Restore^%SYS.PATCH()
%SYS>d$System.CSP.LoadPage("/csp/sys/mgr/UtilConfigSQL.csp","fc")
Compiling file/csp/sys/mgr/UtilConfigSQL.csp
Compiling class%cspapp.mgr.utilconfigsql
Compiling routine%cspapp.mgr.utilconfigsql.1
%SYS>d$System.OBJ.Load("C:\patch\Collection.ListOfDT.xml","fc")
Load started on 04/12/2008 12:17:50
Loading file C:\patch\Collection.ListOfDT.xml as xml
Imported class:%Collection.ListOfDT
Compiling class%Collection.ListOfDT
Compiling routine%Collection.ListOfDT.1
Load finished successfully.
%SYS>d ^%RIMF
Load routines from a%ROMF file.
WARNING: This routine will delete the source code(if any)
for existing object routines that are being replaced.
Device: C:\EnsembleSys\Mgr\FDBMS\qaqcasl523.mro
file format:("UR")=>
M/WNT wrote this file on May 18 2007 3:48 PM.
File Comment: backport of AK626, fix INTO:Array() problem
( All Select Enter List Quit)
Routine Input Option: all
If a selected routine has the same name as one already on file,
shall it replace the one on file? No=> yes
Building existing routine list... done.
@ indicates routines which have been saved to disk.
. indicates routines which already exist in this directory.
Loading Routines...
%qaqcasl@.
1 routine in 0 minutes, 0 seconds
none of them skipped.
%SYS>
%SYS>zn"DHC-APP"
DHC-APP>d$system.SQL.Purge(0)
更改SQL Setting
[Home]> [Configuration]> [SQL Settings]
将DISTINCT optimization turned on的值置为 Yes,保存,然后再置成No保存.
全部做完后把CACHELIB的ReadOnly更改为Yes
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